Zendesk provides support for business rules conditioned by the recipient address in incoming e-mails.

Say you have your SAP specific support requests sent to sap@account.zendesk.com. By setting up a trigger that qualifies the recipient address, you can for example assign that ticket to a specific group and add relevant tags. The trigger condition to test for is "Ticket received at...".

The functionality can also be used to support different customer groups. Say you provide support services for three different companies. By providing them with different support mail addresses and route their tickets to individual groups, you can create custom views for these groups and deal with them individually. A coming release will introduce actual customer organizations, which will take this functionality even further.

All notifications generated by your Zendesk help desk will still come from support@account.zendesk.com regardless of the recipient of the original ticket. But that should be pretty invisible to the end-user.

It goes without saying that you still can map your Zendesk email addresses to addresses in your own domain. For instance:

support@company.com —to—> support@account.zendesk.com
sales@company.com —to—> sales@account.zendesk.com
info@company.com —to—> info@account.zendesk.com
hello@company.com —to—> hello@account.zendesk.com

... and so on.