There are a number of resources to help you set up and use Zendesk. And you can contact support if you have specific issues or questions.
These are the best resources to learn about setting up and using Zendesk:
Using Zendesk is the definitive documentation on all the Zendesk features.
Zendesk webinars are live demonstrations and question and answer sessions about using Zendesk and its features.
Zendesk support forums contain comments, questions, and active discussions about Zendesk best practices and features.
Here are some resources on specific topics that might be of interest to you after you get started. Topics include streamlining your workflow, gaining business insight with reporting, and extending your help desk with integrations.