I would like the ability to delete multiple people\users. Something like a checkbox next to each user, along with a "select\deselect all" link, and then a dropdown action box for bulk changes (delete user, set attributes, mark as spam (like other threads have mentioned). I have searched the forums but only found the post about wanting the ability to mark and remove spam, so this would be along those lines as well.
While not an exact solution for this request (and some of the comments here), we do want to let everyone know about a feature that may help, Bulk User Delete. This tool allows you to delete multiple users at once.